Nursing Implications for ZILEUTON / Zyflo CR

ZILEUTON 
(zi-leu′ton)
Zyflo, Zyflo CR
Classifications: RESPIRATORY SMOOTH MUSCLE RELAXANT; BRONCHODILATOR; LEUKOTRIENE RECEPTOR ANTAGONIST (LTRA)
Therapeutic: BRONCHODILATOR; LTRA
Prototype: Zafirlukast
Pregnancy Category: C

AVAILABILITY 
Immediate release tablet; controlled release tablet

ACTION & THERAPEUTIC EFFECT 

Inhibits 5-lipoxygenase, the enzyme needed to start the conversion of arachidonic acid to leukotrienes, which are important inflammatory agents that induce bronchoconstriction and mucus production. Zileuton helps to prevent the signs and symptoms of asthma including airway edema, smooth muscle constriction, and altered cellular activity due to inflammation.

USES 

Prophylaxis and chronic treatment of asthma in adults and children older than 12 y.

CONTRAINDICATIONS 

Hypersensitivity to zileuton or zafirlukast, active liver disease, status asthmaticus; QT prolongation; lactation.

CAUTIOUS USE 

Hepatic insufficiency; alcoholism; fever; infection; history of QT prolongation; older females; older adults; pregnancy (category C). Safety and effectiveness in children younger than 12 y are not established.

NURSING IMPLICATIONS ZILEUTON / Zyflo CR

Related for Nursing Implications and Drug Information

1. Nuring Implications of ZIPRASIDONE HYDROCHLORIDE
2. NURSING IMPLICATIONS ZIV-AFLIBERCEPT
3. Nursing Implications of ZOLEDRONIC ACID (zo-le-dron′ic)
4. Nursing Implications ZOLMITRIPTAN(zol-mi-trip′tan)
5. Nursing Implications of ZOLPIDEM (zol′-pi-dem)
6. Nursing Implications of ZONISAMIDE

ROUTE & DOSAGE 
Asthma 
Adult/Child (12 y or older):

PO Controlled release: 
1200 mg b.i.d.  OR

Immediate release: 
600 mg q.i.d.

ADMINISTRATION 
Oral 

• Ensure that controlled release tablets are swallowed whole. They should not be crushed or chewed. 
• Store at room temperature, 15°– 30° C (59°–86° F); protect from light. 

ADVERSE EFFECTS

(≥1%) Body as a Whole: Pain, asthenia, myalgia, arthralgia, fever, malaise, neck pain/ rigidity. CNS: Headache, dizziness, insomnia, nervousness, somnolence. CV: Chest pain. GI: Abdominal pain, dyspepsia, nausea, constipation, flatulence, vomiting, elevated liver function tests, asymptomatic hepatitis. Skin: Pruritus. Other: Conjunctivitis, hypertonia, lymphadenopathy, vaginitis, UTI, leukopenia.

INTERACTIONS 

Drug: May double theophylline levels and increase toxicity. Increases hypoprothrombinemic effects of warfarin. May increase levels of BETA-BLOCKERS (especially propranolol), leading to hypotension and bradycardia.

PHARMACOKINETICS 

Absorption: Rapidly from GI tract. Peak: 1.7 h. Duration: 5–8 h. Distribution: 93% protein bound; secreted in the breast milk of rats. Metabolism: In liver primarily via glucuronide conjugation. Elimination: Primarily in urine (94%). Half-Life: 2.5 h.

NURSING IMPLICATIONS 

Assessment & Drug Effects 

• Assess respiratory status and airway function regularly.
• Monitor closely each of the following with concurrent drug therapy: With theophylline, theophylline levels; with warfarin, PT and INR; with phenytoin, phenytoin level; with propranolol, HR and BP for excessive beta blockade. 
• Montior lab tests: Periodic CBC and routine blood chemistry; monthly LFTs for 3 mo, then every 2–3 mo for rest of first year, then periodically. 

Patient & Family Education

• Take medication regularly even during symptom-free periods. 
• Drug is not intended to treat acute episodes of asthma. 
• Report to prescriber promptly S&S of hepatic toxicity (see Appendix F) or flu-like symptoms. Follow-up lab work is very important. 
• Notify prescriber if condition worsens while using prescribed doses of all antiasthmatic medications

Tweet

Jangan sampai ketinggalan postingan-postingan terbaik dari Nursing Implications for Drugs. Berlangganan melalui email sekarang juga:

Atau sobat juga bisa follow Nursing Implications for Drugs dengan mengklik tombol di bawah ini:

Artikel keren lainnya:

Ditulis oleh Unknown pada tanggal Monday, June 29, 2015