Nursing Implications For Trifluridine Viroptic

Trifluridine

(trye-flure′i-deen)

Viroptic

Classification: ANTIVIRAL

Therapeutic: ANTIVIRAL

Pregnancy Category: C

AVAILABILITY

Ophth solution

ACTION & THERAPEUTIC EFFECT

Pyrimidine nucleoside that appears to inhibit viral DNA synthesis and viral replication. Active against herpes simplex virus (HSV) types 1 and 2, vaccinia virus, and certain strains of adenovirus.

USES

Topically to eyes for treatment of primary keratoconjunctivitis and recurring epithelial keratitis caused by herpes simplex virus types 1 and 2. Also for other herpetic ophthalmic infections including stromal keratitis, uveitis, and for infections caused by vaccinia and Adenovirus, but clinical effectiveness has not been established.

CONTRAINDICATIONS

Lactation.

CAUTIOUS USE

Dry eye syndrome; pregnancy (category C); children younger than 6 y.

Nursing Implications For Trifluridine Viroptic

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ROUTE & DOSAGE

Viral Infections of Eye

Adult: Ophthalmic 1 drop 1% ophthalmic solution into affected eye q2h during waking hours until healing (reepithelialization) has occurred (max: 9 drops/day); when healing appears to be complete, dosage reduced to 1 drop q4h during waking hours for an additional 7 days (max: 5 drops/day); continuous administration beyond 21 days not recommended

ADMINISTRATION

Instillation

• Wait several minutes between applications when used concurrently with other eye drops.
• Store refrigerated at 2°–8° C (36°–46° F) unless otherwise directed.

ADVERSE EFFECTS (≥1%)

Special Senses: Mild transient burning or stinging, mild irritation of conjunctiva or cornea, photophobia, edema of eyelids and cornea, punctual occlusion, superficial punctate keratopathy, epithelial keratopathy, stromal edema, keratitis sicca, hyperemia, increased intraocular pressure.

PHARMACOKINETICS

Absorption: Following topical application to eye, trifluridine penetrates cornea and aqueous humor (inflammation enhances penetration). Systemic absorption does not appear to be significant.

NURSING IMPLICATIONS

Assessment & Drug Effects

• Expect epithelial eye infections to respond to therapy within 2–7 days, with complete healing occurring in 1–2 wk.

Patient & Family Education

• Inform prescriber of progress and keep follow-up appointments. Herpetic eye infections have a tendency to recur and can lead to corneal damage if not adequately treated.

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Ditulis oleh Unknown pada tanggal Thursday, September 17, 2015