Triptorelin
Pamoate (trip-tor′e-lyn)
Trelstar Depot, Trelstar LA
Classification: GONADOTROPINRELEASING HORMONE
(GNRH) AGONIST ANALOG
Therapeutic: GNRH AGONIST ANALOG
Prototype: Leuprolide acetate
Pregnancy Category: X
AVAILABILITY
Solution for injection
ACTION
& THERAPEUTIC EFFECT
Synthetic luteinizing releasing hormone agonist (LHRH or GnRH) with
greater potency than naturally occurring luteinizing hormone. Potent inhibitor
of gonadotropin secretion that causes decreased formation of testosterone. In
men, the level of serum testosterone is equivalent to a surgically castrated man.
USES
Palliative treatment of advanced prostate cancer.
UNLABELED
USES
Breast cancer, endometriosis, infertility, hirsutism.
CONTRAINDICATIONS
Hypersensitivity to triptorelin, other LHRH agonists, or LHRH;
dysfunctional uterine bleeding; pregnancy (category X), lactation.
CAUTIOUS
USE
Prostatic carcinoma; hepatic or renal dysfunction; patients with
impending spinal cord compression or severe urogenital disorder; premenstrual
syndrome; renal insufficiency. Safety and effectiveness in children have not
been established.
 |
| Nursing Implications for Trelstar Depot (Triptorelin pamoate) |
ROUTE
& DOSAGE
Prostate Cancer
Adult: IM 3.75 mg qmo OR 11.25 mg q12w or 22.5 mg q24w
ADMINISTRATION
Intramuscular
- Give deep into a large
muscle.
ADVERSE
EFFECTS (≥1%)
Body as a Whole: Hot flushes, pain, leg pain, fatigue. CV: Hypertension. GI: Diarrhea,
vomiting. Hematologic: Anemia. Musculoskeletal: Skeletal pain. CNS:
Headache, dizziness, insomnia, impotence, emotional lability. Skin: Pruritus.
Urogenital: Urinary retention, UTI. Other: Pain at injection
site.
DIAGNOSTIC
TEST INTERFERENCE
May interfere with tests for pituitarygonadal function.
PHARMACOKINETICS
Peak: 1–3 h. Duration: 1
mo. Metabolism: Unknown. Elimination: Eliminated by liver and
kidneys. Half-Life: 3 h.
NURSING
IMPLICATIONS
Assessment & Drug Effects
- Monitor for S&S of
disease flare, especially during the first 1–2 wk of therapy: Increased bone
pain, blood in urine, urinary obstruction, or symptoms of spinal compression.
- Monitor lab tests: Periodic
serum testosterone.
Patient & Family Education
- Disease flare (see ASSESSMENT
& DRUG EFFECTS) is a common,
temporary adverse effect of therapy; however, symptoms may become serious
enough to report to the prescriber.
- Notify prescriber promptly
of the following: S&S of an allergic reaction (itching, hives, swelling of
face, arms, or legs; tingling in mouth or throat, tightness in chest or trouble
breathing); weakness or loss of muscle control; rapid weight gain.
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