Valacyclovir
Hydrochloride
Classification:
ANTIVIRAL
ACTION & THERAPEUTIC EFFECT
An antiviral agent
hydrolyzed in the intestinal wall or liver to acyclovir, which interferes with
viral DNA synthesis. Active against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2),
varicella zoster virus, and cytomegalovirus. Inhibits viral replication.
Herpes zoster (shingles) in
immunocompetent adults. Treatment and suppression of recurrent genital herpes;
suppression of recurrent herpes in HIV-positive patients; treatment of cold
sores.
Hypersensitivity to, or
intolerance of valacyclovir or acyclovir.
Renal impairment, patients
receiving nephrotoxic drugs, advanced HIV disease, allogeneic bone marrow transplant
and renal transplant recipients, treatment of disseminated herpes zoster,
immunocompromised patients, pregnancy (category B); lactation; children younger
than 2 y.
PO 1 g (2 × 500 mg) t.i.d. for 7 days, start within 48 h of onset
of zoster rash
Renal
Impairment Dosage Adjustment
Treatment of
Recurrent Genital Herpes
Adult: PO
500 mg b.i.d. × 3 days
Renal
Impairment Dosage Adjustment
CrCl 29 mL/min or less: 500 mg daily
Suppression
of Recurrent Genital Herpes
Adult: PO
1 g daily; concurrent HIV
infection 500 mg b.i.d.
Adult/Child: PO
2 g 12 h × 2 doses
Adolescent/Child (2 y or older): PO 20 mg/kg t.i.d. × 5 days (max: 1 g t.i.d.)
- Start
drug as soon as possible after diagnosis of herpes zoster, preferably within 48
h of onset of rash.
- Note:
Dosage reduction is recommended for patients with renal impairment.
- Give
valacyclovir after hemodialysis.
- Store at
15°–30° C (59°–86° F).
CNS: Headache, weakness,
somnolence, dizziness, fatigue, lethargy, confusion. GI: Nausea,
vomiting, diarrhea, abdominal pain, dyspepsia,
flatulence. Urogenital: Glomerulonephritis, renal
tubular damage, acute renal failure. Skin: Rash,
urticaria, pruritus.
Drug: Probenecid, cimetidine decrease
valacyclovir elimination. Zidovudine may cause
increased drowsiness and lethargy.
Absorption: Rapidly absorbed from GI tract;
54% reaches systemic circulation as acyclovir. Peak: 1.5 h. Distribution:
13.5–17.9% bound to plasma proteins; distributes into plasma,
cerebrospinal fluid, saliva, and major body organs; crosses placenta; excreted
in breast milk. Metabolism: Rapidly converted to acyclovir
during first pass through intestine and liver. Elimination: 40– 50% in
urine. Half-Life: 2.5–3.3 h.
Assessment & Drug Effects
- Monitor
kidney function in patients with kidney impairment or those receiving
potentially nephrotoxic drugs.
- Monitor for
S&S of hypersensitivity; if present, withhold drug and notify prescriber.
Patient & Family Education
- Be aware of
potential adverse effects and do not discontinue drug until full course is
completed.
- Note:
Post-herpes pain is likely to be present for several months after completion of
therapy.
Nice post. Thanks for sharing this information Valtrex online tablets for herpes.
ReplyDeletegreat information shared, thanks a ton
ReplyDeleteBuy Generic Viagra Online
• This is real take it serious, i am JOHNSON JUDITH i am from Ireland. Who will believe that a herbal medicine can cure HIV/AIDS, I never believe that this will work, i have spend a lot money getting drugs from the hospital to keep me and my son healthy, it got to a point that i was waiting for death to come because i was broke, one day i heard about this great man called Dr ODUWA who is well known for Herpes, HIV, and Cancer cure, i decided to email him I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared a herbal medicine (CURE) and, he gave my details to the Courier Office. they told me that 4-8 days I will receive the package and after receiving it, i took the medicine as prescribed by him at the end of the two weeks, he told me to go to the hospital for a checkup, and i went, surprisingly after the test the doctor confirm me HIV/AIDS negative, and my son and i thought it was a joke, i went to other hospital and was also negative, thank you for saving our life's, I promise I will always testify of your good works. If you are HIV/AIDS patient, contact him and I am sure you will get cured, contact him via: dr.oduwaspellhome@gmail.com or whatsapp him at +2348070685053.
ReplyDeleteTHESE ARE THE THINGS Dr ODUWA CURE
. COLD SORE
. HIV/AIDS
. CANCER
. HPV
. LASSA FEVER
. GONORRHEA
Hello everybody don't just know the reason why some people is finding it difficult to believe that there is a cure for herpes, i have been suffering from herpes since last three years with my boyfriend but today I am happy that am cure from it with the natural herbs cure of Dr.ODUWA the great healer I was browsing the internet searching for help when i came across a testimony shared by someone on how Dr.ODUWA cure his herpes i was so much in need of getting his treatment but after all Dr.ODUWA brought a smile to my face with his natural herbs cure. i am so much happy today that we have someone like this great healer out there, and i know many people are out there looking for cure, why don’t you kindly contact this great healer on his email address: dr.oduwaspellhome@gmail.com please Dr.ODUWA keep your good work cause there are people out there who is in need of your healing medicine. Once more contact him now: dr.oduwaspellhome@gmail.com you can also add him on whatsapp on +2348070685053
ReplyDeleteHiv disease for the last 3 years and had pain hard to eat and cough are nightmares,especially the first year At this stage, the immune system is severely weakened, and the risk of contracting opportunistic infections is much greater. However, not everyone with HIV will go on to develop AIDS. The earlier you receive treatment, the better your outcome will be.I started taking ARV to avoid early death but I had faith in God that i would be healed someday.As a Hiv patent we are advise to be taking antiretroviral treatments to reduce our chance of transmitting the virus to others , few weeks ago i came on search on the internet if i could get any information on Hiv treatment with herbal medicine, on my search i saw a testimony of someone who has been healed from Hiv her name was Achima Abelard and other Herpes Virus patent Tasha Moore also giving testimony about this same man,Called Dr Itua Herbal Center.I was moved by the testimony and i contacted him by his Email.drituaherbalcenter@gmail.com We chatted and he send me a bottle of herbal medicine I drank it as he instructed me to.After drinking it he ask me to go for a test that how i ended my suffering life of Hiv patent,I'm cured and free of Arv Pills.I'm forever grateful to him Drituaherbalcenter.Here his contact Number +2348149277967...He assure me he can cure the following disease..Hiv,Cancer,Herpes Virus,Lyme Disease,Epilepsy, ,Bladder Cancer,Colorectal Cancer,Breast Cancer,Kidney Cancer,Leukemia,Lung Cancer,Non Hodgkin Lymphoma,Skin Cancer,Uterine Cancer,Prostate Cancer, fibromyalgia ,ALS,Hepatitis,Copd,Parkinson disease.Genetic disease,Fibrodysplasia disease,Fibrodysplasia Ossificans Progressiva,Fluoroquinolone Toxicity Syndrome,Inflammatory bowel disease ,Huntington's disease ,Diabetes,Fibroid...
ReplyDeleteAll thanks to Dr. UTU if not for him I don't know what will have become of me today. I married my husband who was HIV positive like myself. We accepted it as fate since there is no cure. Two years after our marriage my life was torn apart when our family doctor diagnosed me of genital herpes virus I know it was from my ex whom I have dated years back. I became very worried because I don't know what will be my husband judgment when he finds out. I searched everywhere both on internet for cure but no success until my husband started suspecting but still he wasn't sure. I don't want to loose my marriage I prayed everyday with hope that there is a cure. I searched without rest blogs, websites, everything google says about herpes and cure and peoples comments one evening after work I was surfing the internet on herpes cure I saw a friend who was giving testimony on how DR. UTU have helped cured her of her herpes virus I immediately contacted her to confirm if her testimony was real. She told me it was. She also told me about African Herbs and Herbalist and Dr Utu. She then gave me Dr. Utu contact, which I contacted him immediately. He told me about his Herbal Medicines and how he has helped many people get healthy with fruits and vegetables and also cured many with his Roots and traditional Herbs, I was interested. He prepared and sent me Herbal medicine for both HERPES & HIV through DHL I used this medicines for both HERPES and HIV carefully as was prescribed by him for 1week and 4days without my husband notice. I waited for a month then went for medical test in a different hospital and I was both herpes and HIV negative I felt reborn. I showed my husband my result and told him everything including DR UTU. He contacted DR UTU who also sent him HIV Herbal Medicine. He used this Medicines for just 8days, then we both went to our family doctor who confirmed my husband HIV negative and me still negative. Our family doctor, Dr Paul is a good Christian and often advice his patients to use natural remedy. Based on confidential he do introduce some of his patients to DR UTU for Herbal cure. If you are sick and want the right Herbal Medicine contact DR UTU on drutuherbalcure@gmail.com
ReplyDeleteGetting rib of Herpes virus wasn't easy, I came across Dr voodoo on how he
ReplyDeletehas cured so many people from herpes and other illness so I decided to give
him a try, now am permanently cured using the natural herbs medication and
cleansing supplement sent by Dr voodoo no more herpes, contact Dr voodoo
WhatsApp number +2348140120719 also e-mail him at:
voodoospelltemple66@gmail.com